Section Cell Biology, Center for Molecular Medicine, University Medical Center Utrecht, The Netherlands
The group of Prof. Judith Klumperman is looking for an outstanding and highly motivated candidate with a master degree in life sciences, biomedical sciences or a related field. The candidate is expected to have a strong background in cell biology, molecular biology, and microscopy. Experience and/or sincere interest in cancer biology and technical microscopy development are required. Furthermore, good communication skills in English are required.
The lab focuses on the role and regulation of the endo-lysosomal system in cellular physiology and disease progression, by developing and using advanced microscopy methods. The lab is based in the Section Cell Biology of the Center for Molecular Medicine, a dynamic institute with international and interactive research groups with direct access to a large number of facilities.
The candidate will work on the project "Defining molecular and cellular modulators of cancer immunotherapy by automated high throughput 3D light-electron microscopy". The main goal will be to identify fundamental mechanisms by which tumor cells modulate their environment to prevent their destruction by the immune system. To that end, state-of-the art microscopy tools will be developed and used to obtain a three-dimensional integrated view on the molecular and cellular factors affecting tumor microenvironment. The project will be carried out as an intensive cooperation with the group of J.P. Hoogenboom in TU Delft and the Lab of Shannon Turley at Genentech, San Francisco.
The PhD position will be for a fixed term of four years and is expected to result in a PhD thesis. Salary and benefits are in accordance with the Collective Labour Agreement for Dutch University Medical Centers.
As a PhD candidate you will be enrolled in the Graduate School of Life Sciences, which is co-organized by three faculties: University Medical Center Utrecht, the Faculty of Veterinary Medicine, and the Faculty of Science. This combination is unique and has gained a strong international reputation in biomedical and life sciences research. The Graduate School of Life Sciences provides an inspiring research environment; an excellent team of supervisors, academic staff and a mentor; and a Doctoral Education Programme aimed at developing your transferable, discipline-related and research skills. Please visit https://www.uu.nl/en/education/graduate-school-of-life-sciences for more information.